Side effects See adverse events or reactions.
Smear A sample, usually sputum for TB diagnosis, spread thinly on a glass slide for staining and examination under a microscope. If a person is "smear-positive," this means that the laboratory found some acid-fast bacilli (AFB), most likely TB bacteria, on their smear.
Sputum A gelatinous or slimy substance (mucous) that is coughed up or induced from deep within the lungs. Should not be confused with saliva or nasal secretions.
Statistical significance The probability that an observed difference in the rate of events (for example, occurrence of TB) between two arms of a vaccine trial is due to chance alone. This probability is determined by using statistical tests to evaluate data collected in a clinical trial. A probability of less than one in 20 (P<.05) that the difference is due to chance is generally considered statistically significant.
Subcutaneous Under the skin. An alternative to the intradermal (within the skin) route of immunization for some vaccines.
Sub-unit vaccine A vaccine consisting of a small piece of a microbe (virus, bacteria) rather than the whole microorganism. This type of vaccine can now be produced by molecular engineering.
Surveillance In medicine, the ongoing collection of information about a disease, such as TB or cancer, in a certain group of people or population. The information collected may include where the disease occurs in a population and whether it affects people of a certain gender, age, or ethnic group.
Symptoms of TB disease Abnormal conditions caused by active TB disease. Important symptoms of pulmonary TB disease include persistent coughing and coughing up sputum or blood. The general symptoms of TB disease (pulmonary or extrapulmonary) include weight loss, fatigue, malaise, fever and night sweats.